Dear MySQL, thanks for your limited regular expression support:
SELECT
REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(REPLACE(name, '2006', ''), '2007', ''), '2008', ''), ' ', ''), '/', ''), '.', ''), '\'', ''), '!', ''), '&', '') AS name,
description
FROM courses;
(Of course I forget to not look a gift horse in the mouth ; )